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GLP-1 receptors agonist such as liraglutide
is approved by the FDA for the treatment of obesity and has shown to cause significant weight loss in conjunction with a reduced calorie diet and increased physical activity.(3) Similarly, PYY analogues are also
being tested as potential weight loss drugs.
A GLP-1 receptor agonist, liraglutide, has been approved by the FDA for the treatment of
obesity and has been shown to cause significant weight loss
in conjunction with a reduced calorie diet and increased physical activity.
We found that G9a/GLP inhibition with either compound reduced anxiety-like behaviors
when administered to adult mice, in conjunction with decreased H3K9
methylation in the brain. Just like GLP1, it acts on the brain to
reduce hunger and promote a feeling of fullness. It also acts on the brain to reduce hunger and promote a feeling of fullness.
GLP-1 signals travel from the gut to the brain via the bloodstream and
the vagus nerve. Microbial metabolites, such as secondary bile acids, short-chain fatty acids, lipopolysaccharide and others within the gut microbiota,
trigger GLP-1 secretion. Likewise, 55% and 63% of people
on 10 mg and 15 mg of tirzepatide, respectively,
achieved at least a 20% body weight reduction (a key secondary
endpoint) compared with 3.1% of those on placebo.